They don't come up often, but big decisions can throw you for a loop if you don't know how to face them. Plus, you're so practical, methodical, and critical that you could dither until the opportunity passes you by or the choice gets made for you.
Before that happens to you, think about your choices. Which one will you regret five or ten years in the future? Your innate caution could steer you away from a risky-looking venture, but sometimes those turn out to be the most rewarding.
Rather than regret a failure, you could wind up regretting the chance not taken. Which will it be?